Codimal PH Syrup

Pronunciation: KOE-deen/fen-ill-EF-rin/peer-IL-a-meen
Generic Name: Codeine/Phenylephrine/Pyrilamine
Brand Name: Examples include Pro-Red AC and Zotex-C

Codimal PH Syrup is used for:

Treating symptoms of the common cold, flu, or hay fever, and other upper respiratory allergies such as cough, congestion, runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes. Codimal PH Syrup may also be used for other conditions as determined by your doctor.

Codimal PH Syrup is a narcotic antitussive (cough suppressant), antihistamine, and decongestant combination. The antitussive works by suppressing the cough center in the brain. The antihistamine works by blocking the action of histamine, which reduces the symptoms of an allergic reaction such as itch, watery eyes and runny nose. The decongestant shrinks swollen nasal passages, which relieves nasal congestion.

Do NOT use Codimal PH Syrup if:

• you are allergic to any ingredient in Codimal PH Syrup or any other codeine-related medicine (eg, dihydrocodeine)


• you have diarrhea associated with poisoning, antibiotic use, or a bacterial infection (from eating or drinking contaminated food or water)


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you are taking sodium oxybate (GHB) or if you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Codimal PH Syrup:

Some medical conditions may interact with Codimal PH Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of alcohol or drug abuse, dependence on narcotics, or suicidal thoughts or behaviors


• if you have increased pressure in the head, an unusual growth in the brain (eg, tumor), a recent head injury, Parkinson disease, Reye syndrome, the blood disease porphyria, or a blockage of your stomach, bowel, or bladder


• if you have a history of epilepsy or seizures, asthma or other breathing problems (eg, sleep apnea), stomach or intestinal problems, chronic constipation, liver problems, glaucoma, an enlarged prostate gland or other prostate problems, difficulty urinating, heart problems, diabetes, high blood pressure, blood vessel problems, adrenal gland problems, overactive thyroid, seizures, or stroke


• if you have recently had abdominal surgery

Some MEDICINES MAY INTERACT with Codimal PH Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturate anesthetics (eg, thiopental), beta-blockers (eg, propranolol), cimetidine, catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, ketorolac, MAO inhibitors (eg, phenelzine), naltrexone, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Codimal PH Syrup may be increased, including dangerous sleepiness and a decrease in the ability to breathe


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Rifampin or risperidone because the effectiveness of Codimal PH Syrup may be decreased


• Bromocriptine or hydantoins (eg, phenytoin) because the actions and side effects may be increased by Codimal PH Syrup


• Guanadrel, guanethidine, mecamylamine, methyldopa, mexiletine, or reserpine because the effectiveness may be decreased by Codimal PH Syrup


• Naltrexone because the effectiveness of Codimal PH Syrup will be decreased and withdrawal symptoms may occur in patients who have become physically dependent on opioids. You must not take naltrexone until you have stopped taking Codimal PH Syrup for 7 to 10 days and after a naloxone challenge test is negative.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Codimal PH Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Codimal PH Syrup:

Use Codimal PH Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Codimal PH Syrup may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Codimal PH Syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Codimal PH Syrup.

Important safety information:

• Codimal PH Syrup may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Codimal PH Syrup. Using Codimal PH Syrup alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.


• Do not drink alcohol while you are using Codimal PH Syrup. Avoid taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Codimal PH Syrup. Codimal PH Syrup will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.


• If your symptoms do not improve within 7 days or if you develop a high fever or persistent headache, check with your doctor.


• Use Codimal PH Syrup with caution in the ELDERLY because they may be more sensitive to its effects, especially possible breathing problems and drowsiness.


• Use Codimal PH Syrup with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: It is unknown if Codimal PH Syrup can cause harm to the fetus. If you become pregnant while taking Codimal PH Syrup, discuss with your doctor the benefits and risks of using Codimal PH Syrup during pregnancy. Codimal PH Syrup is excreted in breast milk. If you are or will be breast-feeding while you are using Codimal PH Syrup, check with your doctor or pharmacist to discuss the risks to your baby.

Use of Codimal PH Syrup can lead to TOLERANCE. When using for an extended period, Codimal PH Syrup may not work as well and may require different dosing. Talk with your doctor if Codimal PH Syrup stops working well.

Long-term use of Codimal PH Syrup can lead to physical DEPENDENCE. The early sign of addiction is medicine ineffectiveness. Dependence is not an issue in terminal illness, when pain relief is more important. If using Codimal PH Syrup for an extended period of time, do not suddenly stop taking Codimal PH Syrup without your doctor's approval. WITHDRAWAL symptoms have occurred when Codimal PH Syrup is suddenly stopped and may include anxiety; diarrhea; fever; runny nose or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping use of Codimal PH Syrup.

Possible side effects of Codimal PH Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, throat, or nose; excitement; nausea; stomach upset; thickening or mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; flushing or redness of face.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Codimal PH side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; coma; confusion; deep sleep or loss of consciousness; difficulty breathing; diminished mental alertness; hallucinations; hot or cold skin; large and unchanging pupils; sedation; seizures; shaking; sleeplessness; slowed breathing; slow heartbeat.

Proper storage of Codimal PH Syrup:

Store Codimal PH Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Codimal PH Syrup out of the reach of children and away from pets.

General information:

• If you have any questions about Codimal PH Syrup, please talk with your doctor, pharmacist, or other health care provider.


• Codimal PH Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Codimal PH Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Codimal PH resources

• Codimal PH Side Effects (in more detail)
• Codimal PH Use in Pregnancy & Breastfeeding
• Codimal PH Drug Interactions
• Codimal PH Support Group
• 0 Reviews for Codimal PH - Add your own review/rating

Compare Codimal PH with other medications

• Cold Symptoms
• Cough and Nasal Congestion

All Day Relief

naproxen sodium

Dosage Form: tablet
Meijer All Day Pain Relief Tablets Drug Facts

Active ingredient (in each tablet)

Naproxen sodium 220 mg

(naproxen 200 mg) (NSAID)*

*nonsteroidal anti-inflammatory drug

Purpose

Pain reliever/fever reducer

Uses

• temporarily relieves minor aches and pains due to:


• minor pain of arthritis


• muscular aches


• backache


• menstrual cramps


• headache


• toothache


• the common cold


• temporarily reduces fever

Warnings

Allergy alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:

• hives


• facial swelling


• asthma (wheezing)


• shock


• skin reddening


• rash


• blisters

If an allergic reaction occurs, stop use and seek medical help right away.

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you

• are age 60 or older


• have had stomach ulcers or bleeding problems


• take a blood thinning (anticoagulant) or steroid drug


• take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)


• have 3 or more alcoholic drinks every day while using this product


• take more or for a longer time than directed

Do not use

• if you have ever had an allergic reaction to any other pain reliever/fever reducer


• right before or after heart surgery

Ask a doctor before use if

• the stomach bleeding warning applies to you


• you have a history of stomach problems, such as heartburn


• you have high blood pressure, heart disease, liver cirrhosis, or kidney disease


• you are taking a diuretic


• you have asthma

Ask a doctor or pharmacist before use if you are

• under a doctor’s care for any serious condition


• taking any other drug

When using this product

• take with food or milk if stomach upset occurs


• the risk of heart attack or stroke may increase if you use more than directed or for longer than directed

Stop use and ask a doctor if

• you experience any of the following signs of stomach bleeding:


• feel faint


• vomit blood


• have bloody or black stools


• have stomach pain that does not get better


• pain gets worse or lasts more than 10 days


• fever gets worse or lasts more than 3 days


• you have difficulty swallowing


• it feels like the pill is stuck in your throat


• you develop heartburn


• redness or swelling is present in the painful area


• any new symptoms appear

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use naproxen sodium during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Directions

• do not take more than directed


• the smallest effective dose should be used


• do not take longer than 10 days, unless directed by a doctor (see Warnings)


• drink a full glass of water with each dose

Adults and children 12 years and older	take 1 tablet every 8 to 12 hours while symptoms last for the first dose you may take 2 tablets within the first hour do not exceed 2 tablets in any 8- to 12-hour period do not exceed 3 tablets in a 24-hour period
Children under 12 years	ask a doctor

Other information

• each tablet contains: sodium 20 mg


• store at 20-25°C (68-77°F). Avoid high humidity and excessive heat above 40°C (104°F).

Inactive ingredients

FD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

Questions or comments?

1-800-719-9260

Principal Display Panel

See New Warnings Information

All Day Relief

Naproxen Sodium Tablets, 220 mg

Pain Reliever/Fever Reducer (NSAID)

Strength to last 12 hours

Actual Size

 Compare to Aleve® active ingredient 

All Day Relief Tablets Carton

All Day Relief  naproxen sodium  tablet

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 41250-490 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength NAPROXEN SODIUM (NAPROXEN) NAPROXEN SODIUM 220 mg

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color BLUE (Light Blue) Score no score Shape ROUND Size 10mm Flavor Imprint Code L490 Contains

Packaging # NDC Package Description Multilevel Packaging 1 41250-490-71 1 BOTTLE In 1 CARTON contains a BOTTLE 1 50 TABLET In 1 BOTTLE This package is contained within the CARTON (41250-490-71) 2 41250-490-78 1 BOTTLE In 1 CARTON contains a BOTTLE 2 100 TABLET In 1 BOTTLE This package is contained within the CARTON (41250-490-78)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA074661	05/29/1997

Labeler - Meijer Distribution Inc (006959555)

Revised: 05/2009Meijer Distribution Inc

More All Day Relief resources

• All Day Relief Side Effects (in more detail)
• All Day Relief Dosage
• All Day Relief Use in Pregnancy & Breastfeeding
• All Day Relief Drug Interactions
• 0 Reviews for All Day Relief - Add your own review/rating

Compare All Day Relief with other medications

• Ankylosing Spondylitis
• Aseptic Necrosis
• Back Pain
• Bursitis
• Costochondritis
• Diffuse Idiopathic Skeletal Hyperostosis
• Dysautonomia
• Fever
• Frozen Shoulder
• Gout, Acute
• Headache
• Juvenile Rheumatoid Arthritis
• Muscle Pain
• Osteoarthritis
• Pain
• Period Pain
• Rheumatoid Arthritis
• Sciatica
• Spondylolisthesis
• Tendonitis

Cyklokapron Tablets

Cyklokapron 500 mg film-coated tablets

Tranexamic acid

Read all of this leaflet carefully before you start taking this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.


• In this leaflet, Cyklokapron 500 mg film-coated tablets will be called Cyklokapron.

In this leaflet:

• 1. What Cyklokapron is for


• 2. Before you take Cyklokapron


• 3. How to take Cyklokapron


• 4. Possible side effects


• 5. How to store Cyklokapron


• 6. Further information.

What Cyklokapron is for

Cyklokapron belongs to a group of medicines called anti-fibrinolytic drugs. These are used to stop or reduce unwanted bleeding. When you bleed your body forms clots to stop the bleeding. In some people these break down causing too much bleeding. Cyklokapron stops these clots dissolving and so reduces unwanted bleeding.

Cyklokapron is used to prevent or reduce bleeding for a short period of time in many different conditions. You may have been prescribed it for one of the following:

• Following prostate surgery (post-prostatectomy)


• Following bladder surgery


• Heavy periods (menorrhagia)


• Nose bleeds (epistaxis)


• Cervical surgery (conisation of the cervix)


• Bleeding inside the eye (traumatic hyphaema)


• Tooth removal (dental extraction) in haemophiliacs (people who bleed more easily than normal). You will know if this refers to you


• A hereditary disease called angioneurotic oedema (HANO). A doctor will have told you if you have this.

Before you take Cyklokapron

Do not take Cyklokapron if:

• You are allergic to tranexamic acid


• You are allergic to any of the other ingredients of Cyklokapron (listed in section 6)


• You have serious problems with your kidneys (kidney failure)


• You have a blood clot in your blood vessels (called a `thrombosis’).

If any of the above applies to you talk to your doctor or pharmacist.

Check with your doctor before taking Cyklokapron if:

• You have blood in your urine


• You have ever had any uncontrollable bleeding


• You have disseminated intravascular coagulation (DIC), a disease where your blood starts to clot throughout your body


• You have been taking medicine to treat a hereditary disease called angioneurotic oedema (HANO) every day for a long time. If so, you may need to have regular eye tests and blood tests to check your liver is working properly


• You are a woman with irregular periods


• You have a history of blood clots in your blood vessels (called a `thrombosis’)


• Anyone in your family has suffered from blood clots in their blood vessels


• You have kidney disease.

If any of the above apply to you, talk to your doctor or pharmacist.

Tell your doctor if you are taking any of the following medicines:

• Fibrinolytic drugs (used to help dissolve blood clots), such as streptokinase. This is because Cyklokapron will stop these drugs working


• Any other medicine, including medicines obtained without a prescription.

Pregnancy and breast-feeding

If you are pregnant, trying to become pregnant or breastfeeding ask your doctor or pharmacist for advice before taking Cyklokapron.

How to take Cyklokapron

Always take Cyklokapron exactly as your doctor has told you.

Important:

Your doctor will choose the dose that is right for you. Your dose will be shown clearly on the label that your pharmacist puts on your medicine. If it does not, or you are not sure, ask your doctor or pharmacist.

Remember: Your medicine should always be taken with a glass of water. The tablets should be swallowed whole. Do not crush or chew them.

Adults and the elderly:

• The usual dose is 2 or 3 tablets taken two to three times daily


• The exact dose you take will depend on why you have been prescribed these tablets


• Follow your doctor’s instructions about how many tablets to take, when to take them and for how long.

Children:

• Your doctor will tell you exactly how much medicine you should give your child. They will work out the dose according to how much your child weighs.

Patients with kidney problems:

• Your doctor will tell you how much to take. The dose you take may be lower than the usual adult dose.

If you take more Cyklokapron than you should

If you accidentally take too much of your medicine, immediately tell your doctor or go to the nearest hospital casualty department.

Taking too much Cyklokapron may make you feel sick, be sick or be dizzy or light-headed upon standing.

If you forget to take Cyklokapron

Do not take a double dose to make up for a missed dose. Simply take the next dose as planned.

If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

Cyklokapron Tablets Side Effects

Like all medicines Cyklokapron can cause side effects, although not everybody gets them.

If you notice any changes in your eyesight or an allergic skin reaction developing, stop taking Cyklokapron and tell your doctor immediately.

Common side effects

• Feeling sick


• Being sick


• Diarrhoea.

These are usually mild and pass very quickly, but if they continue, tell your doctor or pharmacist.

Rare side effects:

• Problems with your eyesight, especially your colour vision


• A blood clot in your eye. This may cause bleeding in the eye, or a loss of vision


• Itchy, red or swollen skin


• A blood clot in your blood vessels (called a `thrombosis’).

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How to store Cyklokapron

Keep out of the reach and sight of children.

Do not use Cyklokapron after the expiry date on the carton. The expiry date refers to the last day of that month.

Do not store above 25 °C.

Medicines should not be disposed of via wastewater or household waste. Return any medicine you no longer need to your pharmacist.

Further information

What Cyklokapron contains:

• The active substance is tranexamic acid. Each tablet contains 500 mg tranexamic acid.


• The other ingredients are microcrystalline cellulose (E460), hydroxypropyl cellulose (E463), talc (E553b), magnesium stearate (E572), colloidal anhydrous silica, povidone (E1201), methacrylate polymers, titanium dioxide (E171), polyethylene glycol 8000, vanillin.

What Cyklokapron looks like

Cyklokapron tablets are white, oblong film-coated tablets. They are marked with CY with an arc above and below the lettering.

The tablets come in plastic bottles containing 50 tablets or in blister packs containing 60 tablets.

Not all pack sizes are marketed.

Marketing Authorisation Holder

Meda Pharmaceuticals Ltd.

Skyway House

Parsonage Road

Takeley

Bishop’s Stortford

CM22 6PU

UK

Manufacturers

MEDA Manufacturing GMBH

Neurather Ring 1

51063 Cologne

Germany

This leaflet was last updated on December 2009

If this leaflet is difficult to see or read, or you would like it in a different format, please contact

Meda Pharmaceuticals Ltd

Skyway House

Parsonage Road

Takeley

Bishop’s Stortford
CM22 6PU

UK

T5004141

Alfuzosin Hydrochloride 2.5mg Tablets

ALFUZOSIN HYDROCHLORIDE


2.5MG TABLETS

Read all of this leaflet carefully before you start taking this medicine.

• Keep this leaflet. You may need to read it again.


• If you have any further questions, ask your doctor or pharmacist.


• This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.


• If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.


• Your doctor may have given you this medicine before from another company. It may have looked slightly different. However, either brand will have the same effect.

In this leaflet:

• 1. What alfuzosin is and what it is used for


• 2. Before you take alfuzosin


• 3. How to take alfuzosin


• 4. Possible side effects


• 5. How to store alfuzosin


• 6. Further information

What Alfuzosin Is And What It Is Used For?

What alfuzosin is

The name of your medicine is Alfuzosin Hydrochloride 2.5mg Tablets (called alfuzosin throughout this leaflet). This belongs to a group of medicines called alpha-blockers.

How alfuzosin works

Alfuzosin can be used to treat the symptoms of Benign Prostatic Hypertrophy.

This is when the prostate gland enlarges (hyperplasia), but the growth is not cancerous (it is benign). It can cause problems in passing water (urine). This happens mainly in older men.

• The prostate gland lies underneath the bladder. It surrounds the urethra. This is the tube that takes your water to the outside of the body.


• If the prostate gets bigger, it presses on the urethra making it smaller. This makes it difficult to pass water.


• Your tablets work by relaxing the prostate gland muscle. This allows the urethra to get bigger and so makes it easier to pass water.

In a few patients with benign prostatic hyperplasia, the prostate gland gets so big that it stops the flow of urine completely. This is called Acute Urinary Retention. This is very painful and you may need a short stay in hospital.

• A thin, flexible tube (catheter) is passed into the bladder. This drains the water and relieves the pain.


• During this time, alfuzosin may be used to help the water to flow again. This has only been shown to help in men aged over 65.

Alfuzosin is used to treat

• Benign Prostatic Hypertrophy

Before You Take Alfuzosin

Do not take alfuzosin and tell your doctor if:

• You are allergic (hypersensitive) to alfuzosin or any of the other ingredients of this medicine (listed in Section 6 below)
  Signs of an allergic reaction include: a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue


• You are taking other alpha-blockers to treat Benign Prostatic Hypertrophy or possibly to lower your blood pressure. See section below on ‘Taking other medicines’.


• You have, or have ever had, something called orthostatic hypotension. This is a drop in blood pressure which usually happens when you stand up. It can make you feel dizzy, light-headed or faint when you stand or sit up quickly


• You have severe liver problems

Do not take this medicine if any of the above apply to you

Take special care and check with your doctor before taking alfuzosin if:

• You have chest pain (angina)


• You have a long term infection in your urinary tract (including your kidneys, bladder and urethra), had difficulty when passing water or had small crystals (stones) forming in the water.


• If you are undergoing eye surgery because of cataract (cloudiness of the lens) please inform your eye specialist before the operation that you are using or have previously used alfuzosin. This is because alfuzosin may cause complications during the surgery which can be managed if your specialist is prepared in advance


• You are allergic (hypersensitive) to other alpha blockers such as doxazosin, tamsulosin


• You are taking medicines for high blood pressure. Your doctor should monitor your blood pressure regularly while you are taking this medicine. This is particularly important at the start of your treatment.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking alfuzosin.

Taking alfuzosin with other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines. This includes medicines you buy without a prescription, including herbal medicines. This is because alfuzosin can affect the way some other medicines work. Also some medicines can affect the way alfuzosin works.

Do not take this medicine, and tell your doctor, if you are taking:

• Other alpha-blockers such as doxazosin, indoramin, prazosin, terazosin, tamsulosin, or phenoxybenzamine.

Tell your doctor if you are taking any of the following:

• A medicine for high blood pressure, as you may get dizzy, weak or start sweating within a few hours of taking this medicine. If this happens, lie down until the symptoms have completely gone. Tell your doctor as he or she may decide to change the dose of your medicine.


• Medicines for fungal infections (such as ketoconazole or itraconazole) and HIV (such as ritonavir).


• Medicines such as glyceryl trinitrate for chest pain (angina)

Operations and tests while taking alfuzosin

• If you are being treated for high blood pressure, your doctor should measure your blood pressure regularly, especially at the start of treatment.


• If you are going to have an operation that needs a general anaesthetic, tell your doctor you are taking alfuzosin before the operation. Your doctor may decide to stop you having alfuzosin 24 hours before the operation.
  This is because it can be dangerous as it can lower your blood pressure.

Taking alfuzosin with food and drink

You may feel dizzy or weak whilst taking alfuzosin. If this happens do not drink any alcohol.

Driving and using machines

You may feel dizzy and weak while taking alfuzosin. If this happens do not drive or operate any tools or machines.

Important information about some of the ingredients of alfuzosin

• 
  Lactose: This is a type of sugar. If you have been told by your doctor that you cannot tolerate some sugars, talk to your doctor before having this medicine.

How To Take Alfuzosin

Always take alfuzosin exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Taking this medicine

• Swallow the tablets whole


• The first dose should be taken just before bedtime


• The actual dose of alfuzosin depends on your needs and the condition being treated but the usual doses are listed below

How much to take

Adults (under 65 years of age)

• The usual dose is one tablet three times a day


• Your doctor may increase this to a maximum of four tablets each day if needed

Elderly (over 65 years of age), patients with high blood pressure or patients with kidney problems

• The usual dose is one tablet in the morning and one tablet in the evening,

Patients with liver problems

• The usual dose is one tablet per day


• Your doctor may increase this to one tablet in the morning and one tablet in the evening

If you take more alfuzosin than you should

Contact your local hospital Accident and Emergency department straight away. Tell the doctor or nurse how many tablets you have taken. Lie down as much as possible to help stop the side effects. Do not try to drive to the hospital yourself.

If you forget to take alfuzosin

Do not take a double dose to make up for a forgotten tablet. Miss it out and then go on as before.

If you stop taking alfuzosin

Keep taking your tablets, even if your symptoms improve. Only stop if your doctor tells you to. The symptoms are better controlled if you continue taking the same dose of this medicine.

If you have any further questions about this medicine, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, alfuzosin can cause side effects, although not everybody gets them.

Stop taking alfuzosin and see a doctor or go to a hospital straight away if:

• You get swelling of the hands, feet, ankles, face, lips or throat which may cause difficulty in swallowing or breathing. You could also notice an itchy, lumpy rash (hives) or nettle rash (urticaria). This may mean you are having an allergic reaction to alfuzosin. This side effect is very rare


• You have chest pain (angina). This usually only happens if you have had angina before. This side effect is very rare


• You get a painful erection of the penis, not related to sexual activity, which will not go away. This side effect has only been reported in a very small number of people taking alfuzosin.

Tell your doctor or pharmacist if any of the following side effects get serious or lasts longer than a few days. Also tell them if you notice any side effects not listed in this leaflet

Common side effects (affects less than 1 in 10 people)

• Feeling dizzy or faint


• Headache


• Feeling sick (nausea)


• Weakness or tiredness


• Diarrhoea


• General feeling of being unwell


• Feeling dizzy, light-headed or faint when you stand or sit up quickly (postural hypotension)


• Dry mouth

Uncommon side effects (affects less than 1 in 100 people)

• A fast heart beat (tachycardia), pounding in the chest and uneven heartbeat (palpitations)


• Chest pain


• Drowsiness


• Rash and itching


• Flushes


• Problems with your vision


• Runny nose, itching, sneezing, stuffy nose and/or burning eyes. These could be symptoms of an allergy


• Water retention (may cause swollen arms of legs)


• Lack of control over passing water

Additional side effects (frequency not known) which may occur are:

• Abnormal liver function (liver problem). Signs may include yellowing of your skin or the whites of your eyes


• Occasionally problems have arisen during cataract surgery in patients taking alfuzosin. If you are due to have eye surgery because of cataract it is important that you tell the specialist before the operation that you are using, or have used, alfuzosin.

If any of the side effects gets serious or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Alfuzosin

• Keep this medicine in a safe place where children cannot see or reach it.


• Store this medicine below 30°C. Store in the original packaging.


• Do not use alfuzosin after the expiry date which is stated on the carton.


• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information

What Alfuzosin Hydrochloride 2.5mg Tablets contain

Each tablet contains 2.5mg of alfuzosin hydrochloride as the active substance.

The other ingredients are, microcrystalline cellulose, lactose, povidone, sodium starch glycollate, magnesium stearate, methylhydroxypropylcellulose, polyethylene glycol 400, titanium dioxide suspension (E171).

What alfuzosin looks like and contents of the pack

Alfuzosin Hydrochloride 2.5mg Tablets are white film-coated tablets marked Xatral 2.5 on one side. They are supplied in blister packs of 60 tablets.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder is:

Winthrop Pharmaceuticals

PO Box 611

Guildford

Surrey

GU1 4YS

UK

Manufacturer is:

Sanofi Winthrop Industrie

30-39 Avenue Gustave Eiffel

3700 Tours

France

This leaflet was last revised in: September 2008

‘Winthrop’ is a registered trademark © 2008 Winthrop Pharmaceuticals.

Kenalog Cream

Generic Name: triamcinolone acetonide

Dosage Form: Cream USP

Kenalog Cream Description

The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents. The steroids in this class include triamcinolone acetonide. Triamcinolone acetonide is designated chemically as 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone. Graphic Formula:

Each gram of 0.025%, 0.1%, and 0.5% Kenalog Cream (Triamcinolone Acetonide Cream) provides 0.25 mg, 1 mg or 5 mg triamcinolone acetonide, respectively, in a vanishing cream base containing propylene glycol, cetearyl alcohol (and) ceteareth-20, white petrolatum, sorbitol solution, glyceryl monostearate, polyethylene glycol monostearate, simethicone, sorbic acid, and purified water.

Kenalog Cream - Clinical Pharmacology

Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions.

The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION).

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Indications and Usage for Kenalog Cream

Kenalog Cream (Triamcinolone Acetonide Cream) 0.025%, 0.1% and 0.5% are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Contraindications

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

Precautions

General

Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients.

Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings.

Therefore, patients receiving a large dose of any potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests, and for impairment of thermal homeostasis. If HPA axis suppression or elevation of the body temperature occurs, an attempt should be made to withdraw the drug, to reduce the frequency of application, substitute a less potent steroid, or use a sequential approach when utilizing the occlusive technique.

Recovery of HPA axis function and thermal homeostasis are generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Occasionally, a patient may develop a sensitivity reaction to a particular occlusive dressing material or adhesive and a substitute material may be necessary.

Children may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (see PRECAUTIONS, Pediatric Use).

If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

These preparations are not for ophthalmic use.

Information for the Patient

Patients using topical corticosteroids should receive the following information and instructions:

1. This medication is to be used as directed by the physician. It is for dermatologic use only. Avoid contact with the eyes.


2. Patients should be advised not to use this medication for any disorder other than for which it was prescribed.


3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.


4. Patients should report any signs of local adverse reactions especially under occlusive dressing.


5. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.

Laboratory Tests

A urinary free cortisol test and ACTH stimulation test may be helpful in evaluating HPA axis suppression.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

Long-term animal studies have not been performed to evaluate the carcinogenic potential or the effect on fertility of topical corticosteroids.

Studies to determine mutagenicity with prednisolone and hydrocortisone showed negative results.

Pregnancy: Teratogenic Effects

Category C. Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women on teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

Nursing Mothers

It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman.

Pediatric Use

Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced HPA axis suppression and Cushing’s syndrome than mature patients because of a larger skin surface area to body weight ratio.

HPA axis suppression, Cushing’s syndrome, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include linear growth retardation, delayed weight gain, low plasma cortisol levels, and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of children.

Adverse Reactions

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings (reactions are listed in an approximate decreasing order of occurrence): burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

Overdosage

Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see PRECAUTIONS, General).

Kenalog Cream Dosage and Administration

Apply Kenalog Cream (Triamcinolone Acetonide Cream) 0.025% to the affected area two to four times daily. Rub in gently.

Apply the 0.1% or the 0.5% Kenalog Cream (Triamcinolone Acetonide Cream), as appropriate, to the affected area two to three times daily. Rub in gently.

Occlusive Dressing Technique

Occlusive dressings may be used for the management of psoriasis or other recalcitrant conditions. Gently rub a small amount of cream into the lesion until it disappears. Reapply the preparation leaving a thin coating on the lesion, cover with pliable nonporous film, and seal the edges. If needed, additional moisture may be provided by covering the lesion with a dampened clean cotton cloth before the nonporous film is applied or by briefly wetting the affected area with water immediately prior to applying the medication. The frequency of changing dressings is best determined on an individual basis. It may be convenient to apply Kenalog Cream under an occlusive dressing in the evening and to remove the dressing in the morning (i.e., 12-hour occlusion). When utilizing the 12-hour occlusion regimen, additional cream should be applied, without occlusion, during the day. Reapplication is essential at each dressing change.

If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

How is Kenalog Cream Supplied

Kenalog Cream® (Triamcinolone Acetonide Cream USP)

0.025%

tubes containing            15 g NDC 0003-0172-22

                                      80 g NDC 0003-0172-68

0.1%

tubes containing            15 g NDC 0003-0506-20

                                      60 g NDC 0003-0506-46

                                      80 g NDC 0003-0506-49

0.5%

tubes containing            20 g NDC 0003-1483-20

Storage

Store at room temperature; avoid freezing.

APOTHECON®

A Bristol-Myers Squibb Company

Princeton, NJ 08540 USA

J3-555F+

January 1994+

KENALOG  triamcinolone acetonide  ointment

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0003-0172 Route of Administration TOPICAL DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength triamcinolone acetonide (triamcinolone) Active 0.25 MILLIGRAM  In 1 GRAM propylene glycol Inactive   cetearyl alcohol (and) ceteareth-20 Inactive   white petrolatum Inactive   sorbitol solution Inactive   glyceryl monostearate Inactive   polyethylene glycol monostearate Inactive   simethicone Inactive   sorbic acid Inactive   water Inactive

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0003-0172-22 15 g (GRAM) In 1 TUBE None 2 0003-0172-68 80 g (GRAM) In 1 TUBE None

KENALOG  triamcinolone acetonide  ointment

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0003-0506 Route of Administration TOPICAL DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength triamcinolone acetonide (triamcinolone) Active 1 MILLIGRAM  In 1 GRAM propylene glycol Inactive   cetearyl alcohol (and) ceteareth-20 Inactive   white petrolatum Inactive   sorbitol solution Inactive   glyceryl monostearate Inactive   polyethylene glycol monostearate Inactive   simethicone Inactive   sorbic acid Inactive   purified water Inactive

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0003-0506-20 15 g (GRAM) In 1 TUBE None 2 0003-0506-46 60 g (GRAM) In 1 TUBE None 3 0003-0506-49 80 g (GRAM) In 1 TUBE None

KENALOG  triamcinolone acetonide  ointment

Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0003-1483 Route of Administration TOPICAL DEA Schedule

INGREDIENTS Name (Active Moiety) Type Strength triamcinolone acetonide (triamcinolone) Active 5 MILLIGRAM  In 1 GRAM propylene glycol Inactive   cetearyl alcohol (and) ceteareth-20 Inactive   white petrolatum Inactive   sorbitol solution Inactive   glyceryl monostearate Inactive   polyethylene glycol monostearate Inactive   simethicone Inactive   sorbic acid Inactive   purified water Inactive

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0003-1483-20 20 g (GRAM) In 1 TUBE None

Revised: 01/2006APOTHECON

More Kenalog Cream resources

• Kenalog Cream Use in Pregnancy & Breastfeeding
• Kenalog Cream Drug Interactions
• Kenalog Cream Support Group
• 22 Reviews for Kenalog - Add your own review/rating

Compare Kenalog Cream with other medications

• Aphthous Ulcer
• Atopic Dermatitis
• Dermatitis
• Lichen Planus
• Psoriasis

Salbutamol Nebuamp

Generic Name: albuterol (Inhalation route)

al-BUE-ter-ol

Commonly used brand name(s)

In the U.S.

• Accuneb


• ProAir HFA


• Proventil


• Proventil HFA


• ReliOn Ventolin HFA


• Ventolin


• Ventolin HFA

In Canada

• Alti-Salbutamol Inhalation Aerosol


• Apo-Salvent


• Salbutamol


• Salbutamol Nebuamp


• Salbutamol Respirator Solution


• Ventolin Inhaler


• Ventolin Nebules P.F.


• Ventolin Respirator


• Ventolin Rotacaps

Available Dosage Forms:

• Aerosol Powder


• Solution


• Capsule


• Powder

Therapeutic Class: Bronchodilator

Pharmacologic Class: Sympathomimetic

Uses For Salbutamol Nebuamp

Albuterol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. This medicine is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm).

Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, albuterol is used in certain patients with the following medical condition:

• Hyperkalemia (too much potassium in the blood).

Before Using Salbutamol Nebuamp

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (e.g., Proair® HFA) in children 4 years of age and older and albuterol inhalation solution (e.g., Accuneb®) in children 2 years of age and older. However, safety and efficacy have not been established for the aerosol in children younger than 4 years of age and for the solution in children younger than 2 years of age.

Geriatric

No information is available on the relationship of age to the effects of albuterol inhalation solution (e.g., Accuneb®) in geriatric patients.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (e.g., Proair® HFA) in geriatric patients. However, elderly patients are more likely to have age-related heart or kidney problems, which may require caution and an adjustment in the dose for patients receiving albuterol.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Alprenolol


• Arotinolol


• Atenolol


• Atomoxetine


• Befunolol


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Brofaromine


• Bucindolol


• Bupranolol


• Carteolol


• Carvedilol


• Celiprolol


• Clorgyline


• Dilevalol


• Esmolol


• Furazolidone


• Iproniazid


• Isocarboxazid


• Labetalol


• Landiolol


• Lazabemide


• Levobetaxolol


• Levobunolol


• Linezolid


• Mepindolol


• Metipranolol


• Metoprolol


• Moclobemide


• Nadolol


• Nebivolol


• Nialamide


• Nipradilol


• Oxprenolol


• Pargyline


• Penbutolol


• Phenelzine


• Pindolol


• Procarbazine


• Propranolol


• Rasagiline


• Selegiline


• Sotalol


• Talinolol


• Tertatolol


• Timolol


• Toloxatone


• Tranylcypromine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Diabetes or


• Heart or blood vessel disease or


• Heart rhythm problems (e.g., arrhythmia) or


• Hypertension (high blood pressure) or


• Hyperthyroidism (overactive thyroid) or


• Hypokalemia (low potassium in the blood) or


• Seizures, history of—Use with caution. May make these conditions worse.

• Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of albuterol

This section provides information on the proper use of a number of products that contain albuterol. It may not be specific to Salbutamol Nebuamp. Please read with care.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine or any asthma medicine without telling your doctor. To do so may increase the chance for breathing problems.

The albuterol inhalation solution (e.g., Accuneb®) should be used with a jet nebulizer that is connected to an air compressor with good air flow. The inhalation solution and nebulizer will come with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use the inhalation solution in the nebulizer:

• Use one container of solution or mix the exact amount of solution using the dropper provided for each dose.


• Place the inhalation solution in the medicine reservoir or nebulizer cup on the machine.


• Connect the nebulizer to the face mask or mouthpiece.


• Use the face mask or mouthpiece to breathe in the medicine.


• Use the nebulizer for about 5 to 15 minutes, or until the medicine in the nebulizer cup is gone.


• Clean all the parts of the nebulizer after each use.

The albuterol inhalation aerosol (e.g., Proair® HFA) is used with a special inhaler that comes with patient instructions. Read the directions carefully before using this medicine. If you or your child do not understand the directions or are not sure how to use the inhaler, ask your doctor to show you what to do. Also, ask your doctor to check you or your child on a regular basis to make sure you are using it properly.

To use the aerosol inhaler:

• The inhaler should be at room temperature before you use it.


• Insert the metal canister firmly and fully into the clear end of the Proair® HFA mouthpiece. This mouthpiece should not be used with other inhaled medicines.


• Remove the cap and look at the mouthpiece to make sure it is clean.


• Shake the inhaler well and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for more than 2 weeks.


• To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright.


• Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister.


• Hold your breath for about 10 seconds, then breathe out slowly.


• If you are supposed to use more than one puff, wait 1 minute before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler.


• When you have finished all of your doses, rinse your mouth with water and spit the water out.


• Clean the inhaler mouthpiece at least once a week with warm running water for 30 seconds, and dry it completely.


• If you need to use the inhaler before it is completely dry, shake off the excess water, replace the canister, and spray it 2 times in the air away from the face. Use your regular dose.


• After using the inhaler, wash the mouthpiece again and dry it completely.


• If the mouthpiece becomes blocked, washing it will help.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inhalation aerosol dosage form (inhaler):
  
  • For preventing bronchospasm:
    
    • Adults, teenagers, and children 4 years of age and older—Two puffs every 4 to 6 hours as needed.
    
    
    • Children younger than 4 years of age—Use and dose must be determined by your child's doctor.
    
    
  
  
  • For preventing exercise-induced bronchospasm:
    
    • Adults, teenagers, and children 4 years of age and older—Two puffs taken 15 to 30 minutes before exercise.
    
    
    • Children younger than 4 years of age—Use and dose must be determined by your child's doctor.
    
    
  
  


• For inhalation solution dosage form (used with a nebulizer):
  
  • For preventing bronchospasm:
    
    • Adults and children older than 12 years of age—2.5 milligrams (mg) in the nebulizer 3 or 4 times per day as needed.
    
    
    • Children 2 to 12 years of age—0.63 to 1.25 mg in the nebulizer 3 or 4 times per day as needed.
    
    
    • Children younger than 2 years of age—Use and dose must be determined by your child's doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Salbutamol Nebuamp

It is very important that your doctor check the progress of you or your child at regular visits. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

This medicine should not be used together with other inhaled medicines that are similar, such as isoproterenol (Isuprel®), levalbuterol (Xopenex™), metaproterenol (Alupent®), pirbuterol (Maxair®), or terbutaline (Brethaire®).

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Stop using this medicine and check with your doctor right away if you or your child have coughing, difficulty breathing, shortness of breath, or wheezing after using this medicine.

Talk to your doctor or get medical help right away if:

• Your symptoms do not improve or they become worse after using this medicine.


• Your inhaler does not seem to be working as well as usual and you need to use it more often.

You or your child may also be taking an antiinflammatory medicine, such as a steroid (cortisone-like medicine), together with this medicine. Do not stop taking the antiinflammatory medicine, even if your asthma seems better, unless you are told to do so by your doctor.

Albuterol may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and check with your doctor right away if you or your child develop a skin rash, hives, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Hypokalemia (low potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you or your child have more than one of the following symptoms: convulsions; decreased urine; dry mouth; increased thirst; irregular heartbeat; loss of appetite; mood changes; muscle pain or cramps; nausea or vomiting; numbness or tingling in the hands, feet, or lips; shortness of breath; or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Salbutamol Nebuamp Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Fast, irregular, pounding, or racing heartbeat or pulse


• shakiness in the legs, arms, hands, or feet


• trembling or shaking of the hands or feet

Less common

• Abdominal or stomach pain


• bladder pain


• bloody or cloudy urine


• chest discomfort


• chest pain


• cough or hoarseness


• cough producing mucus


• diarrhea


• difficult or labored breathing


• difficulty with swallowing


• dizziness


• feeling of warmth


• fever or chills


• frequent urge to urinate


• hives


• itching


• loss of appetite


• lower back or side pain


• nausea


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• redness of the face, neck, arms, and occasionally, upper chest


• runny nose


• shortness of breath


• skin rash


• sore throat


• swollen, painful, or tender lymph glands in the neck, armpit, or groin


• tightness in the chest


• unusual tiredness or weakness


• weakness


• wheezing

Rare

• Hives or welts


• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs


• noisy breathing


• redness of the skin


• swelling of the mouth or throat


• trouble breathing

Incidence not known

• Agitation


• anxiety


• arm, back, or jaw pain


• chest tightness or heaviness


• confusion


• convulsions


• decreased urine


• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position


• drowsiness


• dry mouth


• extra heartbeats


• fainting


• flushed, dry skin


• fruit-like breath odor


• hallucinations


• headache


• increased hunger


• increased thirst


• increased urination


• irritability


• lightheadedness


• muscle pain or cramps


• nervousness


• nightmares


• numbness or tingling in the hands, feet, or lips


• pounding in the ears


• rapid, deep breathing


• restlessness


• shakiness


• slow or fast heartbeat


• stomach cramps


• sweating


• unexplained weight loss


• unusual feeling of excitement


• vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Body aches or pain


• congestion


• fever


• runny nose


• tender, swollen glands in the neck


• trouble with swallowing


• voice changes

Less common

• Difficult, burning, or painful urination


• earache


• headache, severe and throbbing


• muscle or bone pain


• pain


• redness of the skin


• redness or swelling in the ear


• redness, swelling, or soreness of the tongue


• sleeplessness


• sneezing


• stuffy nose


• swelling


• tenderness


• trouble in holding or releasing urine


• trouble sleeping


• unable to sleep


• warmth on the skin

Rare

• Sleepiness or unusual drowsiness

Incidence not known

• Bad, unusual, or unpleasant (after) taste


• change in taste


• feeling of constant movement of self or surroundings


• gagging


• rough, scratchy sound to voice


• sensation of spinning


• tightness in the throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Salbutamol Nebuamp side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Salbutamol Nebuamp resources

• Salbutamol Nebuamp Side Effects (in more detail)
• Salbutamol Nebuamp Use in Pregnancy & Breastfeeding
• Drug Images
• Salbutamol Nebuamp Drug Interactions
• Salbutamol Nebuamp Support Group
• 34 Reviews for Salbutamol Nebuamp - Add your own review/rating

Compare Salbutamol Nebuamp with other medications

• Asthma, acute
• Asthma, Maintenance
• Bronchospasm Prophylaxis
• COPD, Acute
• COPD, Maintenance

Jiexin

Jiexin may be available in the countries listed below.

Ingredient matches for Jiexin

Pegfilgrastim

Pegfilgrastim is reported as an ingredient of Jiexin in the following countries:

• China

International Drug Name Search